Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs.

Current and Future Oncology Management in the United States

The Scripps Research Molecular Screening Center (SRMSC) was founded in 2004 and comprises more than $22 million of specialized automation. As part of the Translational Research Institute (TRI), it comprises early drug discovery labs and medicinal chemistry.

Together with Scripps Research at the La Jolla, California, campus, this represents one of the most competitive academic industrial screening centers worldwide. The SRMSC uses automated platforms, one a screening cell and the other a cherry-picking platform. Matched technologies are available throughout Scripps to allow scientists to develop assays and prepare them for automated screening. The library comprises more than 1 million drug-like compounds, including a proprietary collection of >665,000 molecules. Internal chemistry has included ~40,000 unique compounds that are not found elsewhere.

These collections are screened against a myriad of disease targets, including cell-based and biochemical assays that are provided by Scripps faculty or from global investigators. Scripps has proven competence in all detection formats, including high-content analysis, fluorescence, bioluminescence resonance energy transfer (BRET), time-resolved fluorescence resonance energy transfer (TR-FRET), fluorescence polarization (FP), luminescence, absorbance, AlphaScreen, and Ca++ signaling. These technologies are applied to NIH-derived collaborations as well as biotech and pharma initiatives.

The SRMSC and TRI are recognized for discovering multiple leads, including Ozanimod.

The prevailing philosophy in biological testing has been to focus on simple tests with easy to interpret information such as ELISA or lateral flow assays.

Current and Future Oncology Management in the United States
Current and Future Oncology Management in the United States

At the same time, there has been a decades long understanding in device physics and nanotechnology that electrical approaches have the potential to drastically improve the quality, speed, and cost of biological testing provided that computational resources are available to analyze the resulting complex data.

This concept can be conceived of as “the internet of biology” in the same way miniaturized electronic sensors have enabled “the internet of things.” It is well established in the nanotechnology literature that techniques such as field effect biosensing are capable of rapid and flexible biological testing.

Until now, access to this new technology has been limited to academic researchers focused on bioelectronic devices and their collaborators. Here we show that this capability is retained in an industrially manufactured device, opening access to this technology generally.

Access to this type of production opens the door for rapid deployment of nanoelectronic sensors outside the research space. The low power and resource usage of these biosensors enables biotech engineers to gain immediate control over precise biological and environmental data.

The Complexity of Compliance in Sample Management: A Review of Key Issues Impacting Small-Molecule and Biological Sample Management in Early Drug Discovery.

Current and Future Oncology Management in the United States

The discovery of new medicines has become increasingly more challenging and requires significant collaboration between pharma, biotech, academia, and technology to be successful.

These partnerships necessitate the streamlined exchange of samples while adhering to the increasingly complex set of legal and proprietary restrictions, government legislation, and ethical considerations associated with samples. There is a significant volume of literature published on clinical sample compliance but little describing compliance aspects of discovery sample management.

This paper describes some of the key compliance activities and challenges and shares GlaxoSmithKline’s experiences and current practices.

Synthetic biology is an established but ever-growing interdisciplinary field of research currently revolutionizing biomedicine studies and the biotech industry.

The engineering of synthetic circuitry in bacterial, yeast, and animal systems prompted considerable advances for the understanding and manipulation of genetic and metabolic networks; however, their implementation in the plant field lags behind.

Here, we review theoretical-experimental approaches to the engineering of synthetic chemical- and light-regulated (optogenetic) switches for the targeted interrogation and control of cellular processes, including existing applications in the plant field.

We highlight the strategies for the modular assembly of genetic parts into synthetic circuits of different complexity, ranging from Boolean logic gates and oscillatory devices up to semi- and fully synthetic open- and closed-loop molecular and cellular circuits.

Finally, we explore potential applications of these approaches for the engineering of novel functionalities in plants, including understanding complex signaling networks, improving crop productivity, and the production of biopharmaceuticals.

Current and Future Oncology Management in the United States
Current and Future Oncology Management in the United States

Adeno-associated virus (AAV) vectors currently represent the most attractive platform for viral gene therapy and are also valuable research tools to study gene function or establish disease models.

Consequently, many academic labs, core facilities, and biotech/pharma companies meanwhile produce AAVs for research and early clinical development. Whereas fast, universal protocols for vector purification (downstream processing) are available, AAV production using adherent HEK-293 cells still requires time-consuming passaging and extensive culture expansion before transfection.

Moreover, most scalable culture platforms require special equipment or extensive method development. To tackle these limitations in upstream processing, this study evaluated frozen high-density cell stocks as a ready-to-seed source of producer cells, and further investigated the multilayered CELLdisc culture system for upscaling.

The results demonstrate equal AAV productivity using frozen cell stock-derived cultures compared to conventionally cultured cells, as well as scalability using CELLdiscs.

Thus, by directly seeding freshly thawed cells into CELLdiscs, AAV production can be easily upscaled and efficiently standardized to low-passage, high-viability cells in a timely flexible manner, potentially dismissing time-consuming routine cell culture work. In conjunction with a further optimized iodixanol protocol, this process enabled supply to a large-animal study with two high-yield AAV2 capsid variant batches (0.6-1.2 × 1015 vector genomes) in as little as 4 weeks.

Current and Future Oncology Management in the United States

Current and Future Oncology Management in the United States

The cost of treating cancer patients is high and rising in the United States. Payers are exposed to cost through doctor visits, laboratory tests, imaging tests, radiation treatment, drugs, hospital stays, surgery, home care, transportation and travel, and caregiving.

This study focuses on the cost of medication from the viewpoint of U.S. payers. Although new tools for managing these costs have been gaining attention, prices continue to rise, and challenges to managing costs remain high. Innovative tools are necessary for controlling the cost of care in oncology, but their effectiveness is still unclear.

To (a) gauge payer perceptions of current and future cost management of innovative oncology drugs and (b) predict which management tools will increase in prevalence by 2020-2022.A literature search of cost and management of oncology created the foundation for developing a survey for U.S. payers. The mobile survey was completed on devices such as smart phones or tablets.

Current and Future Oncology Management in the United States
Current and Future Oncology Management in the United States

Payers were asked about general oncology product management, use of specific management tools today, management challenges, and expected use of specific management tools in 2020-2022. Management tools were segmented into traditional (used across many therapeutic categories), oncology-specific (used in oncology but not routinely used in other disease areas), and systemic (not product-specific but that affect the way services are provided and funded).

Specific questions for managing the cost of care in non-small cell lung cancer (NSCLC) and chronic lymphocytic leukemia (CLL) were included in the survey. NSCLC and CLL were chosen because of their diverse clinical characteristics and the level of innovation in these disease areas.

The survey was fielded from May 31, 2017, to June 15, 2017. Results consisted of simple descriptive statistical analysis weighted by the payer’s reported organizational covered lives.Payers were concerned with the high cost and budget impact of oncology drugs and considered these a high priority for management.

However, they continue to use traditional management tools such as manage to FDA label, quantity limits, step edits, and reauthorizations, which are ineffective in controlling cost.

More innovative management tools such as pathways of care are available but are not yet widely adopted. Payers hope to better control oncology cost in the future; however, specific questions pertaining to the management of NSCLC and CLL indicate that minimal changes in cost management will occur by 2020-2022.Despite an increasing number of innovative cost management tools, challenges remain for managing oncology medication costs.

New incentives are being generated, but barriers to their implementation will continue to restrict use through 2020-2022.No outside funding supported this study. The authors are employed by MKO Global Partners, which is a consulting firm that focuses on payer strategy and market access in the pharmaceutical and biotech markets. Some initial results from this research were published as part of a comparative poster at ISPOR European Conference; November 4-8, 2017; Glasgow, Scotland, UK.

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  663. Nuchek
  664. Clare Chemical
  665. Invitek Gmbh
  666. Cambridge Bioscience
  667. Idlabs
  668. Biohelix
  669. Pishtaz Teb Zaman Diagnostics
  670. Biohit Inc.
  671. Encor Biotechnology
  672. Jointproteincentral
  673. Oxisresearch
  674. Veridex
  675. Quickzyme Biosciences
  676. Nalge Nunc
  677. Systembiosciences
  678. Miniplast Ein-Shemer
  679. Ameritech Biomedicines
  680. Novatec Immundiagnostica
  681. Ascentscientific
  682. Emfret
  683. Incell Corporation
  684. Lectinity
  685. Topogen
  686. Plasmidfactory
  687. Innovativecelltech
  688. Inalcopharm
  689. Iba-Go
  690. Nu-Chekprep
  691. Polymun
  692. Hitachi High Technologies America, Inc.
  693. Bio Express
  694. Cellsciences
  695. Roboz
  696. Bioexpress
  697. Rbc Bioscience
  698. Synbiotics Corporation
  699. Panvera
  700. Bindingsite
  701. Everest Biotech
  702. Registech
  703. Scientechcorp
  704. Syd Labs
  705. Affinity Biologicals
  706. More-Bio
  707. Prosci Incorporated
  708. Bioabb
  709. Koma Biotechnology
  710. Biozol
  711. Caliper Lifesciences
  712. Capricorn Products
  713. Cellchip
  714. Exiqon
  715. R-Biopharm
  716. Rural Technologies
  717. Viennalab
  718. Virostat
  719. Avantilipids
  720. Microgen Bioproducts
  721. Camycal
  722. Kentscientific
  723. Accurate Chemical
  724. Ibex Phatmaceuticals Inc
  725. Kalenbio
  726. Calypte
  727. R And D Systems
  728. Axxora
  729. Kent Scientific
  730. Wpiinc
  731. Immunostar
  732. Bussetti
  733. Macrocyclics
  734. Maxim Biotech
  735. National Veterinary Services Laboratories
  736. Gennpova
  737. Genisphere
  738. Nichiryo
  739. Aristabiologicals
  740. Incelldx
  741. Neuromab
  742. Schebo
  743. Americanpeptide
  744. Physitemp
  745. Arista Biologicals
  746. Smartox
  747. Iic-International Immunology Corporation
  748. St John’S Laboratory
  749. Everestbiotech
  750. Lumigen
  751. Solulink
  752. Genaxxon
  753. Icpbio
  754. Combi-Blocks
  755. Hazard Technology Company Inc.
  756. Laebio
  757. Rockland Immunochemicals, Inc.
  758. A.G Scientific
  759. Microspheres-Nanospheres
  760. Seikagaku
  761. Mabtech Ab
  762. D-Gen
  763. Mbl International Corporation
  764. Aviscera
  765. Extrasynthese
  766. Goldbio
  767. Integralmolecular
  768. System Biosciences
  769. Icllab
  770. Ameribiopharma
  771. Biognostik
  772. Applied Biological
  773. Clare Chemical Research
  774. Immunocellular
  775. Mrbiotech
  776. Qbiogene
  777. Nu Chek
  778. Quantimetrix Corporation
  779. Qa-Bio
  780. Sicgen
  781. Antigenix America
  782. Stressmarq Biosciences
  783. Nu-Chek
  784. Amocol
  785. Ascent Scientific
  786. Assay Biotech
  787. Gilson Inc.
  788. Haematologic Technologies
  789. Medip Kit
  790. Virion-Serion
  791. Neuromics
  792. Nugen Tech
  793. Chemicell
  794. Ebiosource
  795. Pcna Antigen
  796. Percipio Biosciences
  797. Euromedex
  798. Proteus Biosciences
  799. Acanthusresearch
  800. Assaybiotech
  801. Delta Biolabs
  802. Biogenes
  803. Expedeon
  804. Hyvac Products Incorporated
  805. Bellco Glass Inc
  806. Rpeptide
  807. Aat Bioquest Inc
  808. Sioux Biochemical
  809. Cellbiology Utrecht
  810. Trilink Biotechnologies
  811. Dualsystems
  812. Immuquest
  813. Technoclone
  814. Bioreclamationivt
  815. Friedrich And Dimmock Inc.
  816. Indofine
  817. Db Biotech
  818. H-B Instrument Company
  819. Iq Scientific / Hach Company
  820. Nordicmubio
  821. Anogen
  822. Cell Marque
  823. De Novo Software
  824. Labvision
  825. Larodan
  826. Rel Assay Diagnostics
  827. Axon Medchem
  828. Arbor Assays
  829. Assay Pro
  830. Bioassaysys
  831. Biogenex
  832. Cytomark
  833. Expressbio
  834. Mitosciences
  835. Oxford Expression Technologies
  836. Pharmalab
  837. Spherotech
  838. Vectorlabs
  839. Covalab
  840. Sungene Biotech
  841. Cellscript
  842. Biaseparations
  843. Innovabiosciences
  844. Mbl International
  845. Advanced Biotechnologies Incorporated
  846. Bellcoglass
  847. Dade-Behring
  848. Assaydesigns
  849. Genwaybio
  850. Porphychem
  851. Epoch Life Science
  852. Proteochem
  853. Schebo Biotech
  854. Phoenixpeptide
  855. Signalchem
  856. Rd Biotech
  857. Magnamedics
  858. Panpath
  859. Sandia Biotech
  860. Finescience
  861. Sabiosciences
  862. Abdserotec
  863. Genlantis
  864. Applygen
  865. Epicentre Biotechnologies
  866. Icp Bio
  867. Oz Bio
  868. Promab
  869. Athens Research And Technology
  870. Glen Research
  871. Genemay
  872. Luminex Corporation
  873. Genemed
  874. Zymoresearch
  875. Innogenetics
  876. Nichirei Biosciences
  877. Anawa
  878. Angiobio
  879. Ibi Scientific
  880. Pluriselect
  881. Silantes
  882. Synaptic Systems
  883. Takara Bio Inc
  884. Biomarket
  885. Biomoles
  886. Biospec
  887. Crystal Chem
  888. Elisasystems
  889. Listlabs
  890. Oxford Genetics
  891. Trlink
  892. Calbioreagents
  893. Gilson Co. Inc.
  894. Aves Labs
  895. Integrated Dna Technologies
  896. Source Bioscience Microrna
  897. Vivantis
  898. Openbiosystems
  899. Zyagen
  900. Edgebio
  901. Empire Genomics Fish
  902. Adventbio
  903. Abfrontier
  904. Repligen
  905. Ted Pella
  906. 4Adi
  907. Dna Genotek Inc.
  908. Imgenex
  909. Mpbio
  910. Polymer Factory
  911. Pbl Interferonsource
  912. Vmrd
  913. Symansis
  914. Immnuolab
  915. Immunotools
  916. Biosense Laboratories
  917. Cytognos
  918. Dualsystems Biotech
  919. Mobitec
  920. Seralab
  921. Stremchemical
  922. Fitzgerald Industries
  923. Ascentgene
  924. Grace Bio-Labs
  925. Jenabioscience
  926. Xenotech
  927. Diagenode
  928. Proteus Bioscience
  929. Abgab
  930. Developmental Studies Hybridoma Bank
  931. Gbiosciences
  932. Glass-Bottom-Dishes
  933. Prospec-Tany Technogene
  934. Agrisera
  935. Biolamina
  936. Li-Cor Biosciences
  937. Affixscientific
  938. Biocytex
  939. Cosmobio
  940. Dsllabs
  941. Enzo Life Sciences
  942. Labnet International Inc
  943. Sourcebioscience
  944. Unitedbiomedical
  945. Antigenix
  946. Cellutions Biosystems
  947. Nacalai Tesque
  948. Nacalai Tesque, Inc.
  949. Alpha Diagnostics
  950. Assay Designs(Stressgen)
  951. Ch3 Biosystems
  952. Enzyme Research Laboratories
  953. Molecular Devices Corporation
  954. Polypure
  955. Applichem
  956. Assay Designs
  957. Bma Biomedicals
  958. Boehringer Mannheim
  959. Chempep
  960. Cliawaived
  961. Hirschmann Inc. Lab Equip.
  962. Hyglos Gmbh
  963. Kane International
  964. Kord-Valmark
  965. Macherey-Nagel
  966. Platypus Technologies
  967. Prokazyme
  968. Southernbiotech
  969. Us Biological
  970. Associates Of Cape Cod
  971. Invirion
  972. Kreatech Diagnostics
  973. Signosis
  974. Edc Biosystems
  975. Immuno-Cell
  976. Proteintech Group
  977. Avivasysbio
  978. Prospecbio
  979. Abvision
  980. Enzyme Research
  981. Nvsl
  982. Itsi-Biosciences
  983. Selectively Desulphated Heparins
  984. Creative Biomart
  985. Gene Bridges Gmbh
  986. Hyglos
  987. Nest Group
  988. Immunovision
  989. Immunoreagents Inc
  990. Swant
  991. Abiocode
  992. Helveticahealthcare
  993. Isconova
  994. Immbio
  995. Bioassay Systems
  996. Kamiya Biomedical
  997. Plactest
  998. Plant-Media
  999. Vector Laboratories
  1000. Biomol
  1001. Eurogentec
  1002. Open Biosystems
  1003. Zen-Bio
  1004. Fibercell
  1005. Immunolab Gmbh Kassel
  1006. Genebridege
  1007. Glenresearch
  1008. Usbio
  1009. Arotec Diagnostics
  1010. Iduron
  1011. Kollodis Biosciences
  1012. Evrogen
  1013. Hycor
  1014. Crystalchem
  1015. Viagen
  1016. Abbiotec
  1017. Acris-Antibodies
  1018. Bellco Glass, Inc.
  1019. Bio-Quant Inc.
  1020. Bps Bioscience
  1021. Calbiochem
  1022. Cedarlane
  1023. Cell Sciences
  1024. Cospheric-Microspheres
  1025. Geneseesci
  1026. Lifespan Biosciences
  1027. Medicago Ab
  1028. Nanotools
  1029. Stratagene
  1030. Tedpella
  1031. Acris Antibodies
  1032. Celltechnology
  1033. Moltox
  1034. Phoenix Pharmaceuticals
  1035. Prime Diagnostics
  1036. Biotium
  1037. Tncbio
  1038. Biotx
  1039. Lab Vision Corporation
  1040. Oligoengine Psuper
  1041. Altogen Biosystems
  1042. Creative-Biomart
  1043. Endotrap
  1044. Polyscience
  1045. Southern Biotech
  1046. Hycorbiomedical
  1047. Abd Serotec
  1048. Meridianlifescience
  1049. Genway Biotech
  1050. Astarte Biologics
  1051. Chinagen
  1052. Lee Biosolutions
  1053. Neoclone
  1054. Rieke Metals
  1055. Sbi System Biosciences
  1056. Sysy
  1057. Transgenomic
  1058. Htslabs
  1059. Bellbrooklabs
  1060. Biomedical Technologies
  1061. Cellbiolabs
  1062. Chondrex
  1063. Immunolab
  1064. Ingenasa
  1065. Jena Bioscience
  1066. Proteintech
  1067. Worthington
  1068. Alomone Labs
  1069. A-M Systems
  1070. Cayman Chemicals
  1071. Complement Technology
  1072. Id-Vet
  1073. Immuno Concepts
  1074. Life Technologies Corporation
  1075. Ludge
  1076. Nanobac
  1077. New England Biolabs
  1078. American Peptide
  1079. Oz Biosciences
  1080. Sierra Sensors
  1081. Hycultbiotech
  1082. Megazym
  1083. Milenia Biotec
  1084. Laysanbio
  1085. Kapabiosystems
  1086. Cypex
  1087. Bellbrook Labs
  1088. Pjk Gmbh
  1089. American Diagnostica Inc
  1090. Angio-Proteomie
  1091. Bioswamp
  1092. Cellgro
  1093. Columbia Biosciences
  1094. Crystalgen
  1095. Earthox
  1096. Ez Biosystems
  1097. Insitus
  1098. Lc Laboratories
  1099. Lumiprobe
  1100. Novagen
  1101. Selleckchem
  1102. Trigene
  1103. Spring Valley Laboratories
  1104. Altromin
  1105. Kapa Biosystems
  1106. Reprocell
  1107. Source Bioscience Sirna
  1108. Biomeda
  1109. Active Motif
  1110. Genetex
  1111. Harlan Teklad
  1112. Intronbio
  1113. Medix Biochemica
  1114. Trevigen
  1115. Aviva Systems Biology
  1116. Chromadex
  1117. Cisbio International
  1118. Valleybiomedical
  1119. Abmgood
  1120. Hycult Biotech
  1121. Activemotif
  1122. Amresco Inc.
  1123. Axygen Scientific
  1124. Bioassay
  1125. Cisbio
  1126. Cosmo Bio
  1127. International Immunology Corporation
  1128. Invitek
  1129. Invitria
  1130. Midland Certified Reagent Company
  1131. Scantibodies
  1132. Corning
  1133. Ebioscience
  1134. Eurogen
  1135. Fitzgerald
  1136. Lktlabs
  1137. Spring Bioscience
  1138. Antibody Stabilizer
  1139. Biosb
  1140. Hyclone
  1141. Hytest
  1142. Koma Biotech
  1143. Panomics
  1144. Tocris
  1145. Virogen
  1146. Kalen Biomedical
  1147. Equitech
  1148. Serotec
  1149. Biofx
  1150. Oxis International Inc
  1151. Stemrd
  1152. Zymed
  1153. Candor Bioscience
  1154. Enzolife
  1155. Antibodies-Online
  1156. Biooscientific
  1157. Biorbyt
  1158. Discoverx
  1159. Equitech-Bio
  1160. Fujirebio
  1161. Gendepot
  1162. Gen-Probe
  1163. Gracebio-Labs
  1164. Prozyme
  1165. Immunodiagnostik
  1166. Jaica
  1167. Sanquin
  1168. Acrobiosystems
  1169. Aesku
  1170. Biocare
  1171. Genesee Scientific
  1172. Hycult Biotechnology
  1173. Immunovaccine Technologies
  1174. Novabiochem
  1175. Organotechnie
  1176. Selleck Chemicals
  1177. Sunnylab
  1178. Anaspec
  1179. Anatrace
  1180. Bioclone
  1181. Biogenova
  1182. Diaclone
  1183. Isosep Ab
  1184. Novus
  1185. Phenomenex
  1186. Proimmune
  1187. Sebia
  1188. Vistalab
  1189. Genecopoeia
  1190. Lucerna Technologies
  1191. Sanbio
  1192. Enogene
  1193. Innopsys
  1194. Novoprotein
  1195. Sinobio
  1196. Miltenly
  1197. Phosphosolution
  1198. Biospacific
  1199. Diasorin
  1200. Ingeny
  1201. Mubio
  1202. Peviva
  1203. Seramun
  1204. Ubpbio
  1205. Vitlab
  1206. Fdneuroo
  1207. Nanolight Technologies
  1208. Chantest
  1209. Creative-Bioarray
  1210. Gracebio
  1211. Biosensis
  1212. Monobind
  1213. Badrilla
  1214. Humanzyme
  1215. Immunogold
  1216. Leinco
  1217. 3-M Company
  1218. A&D Weighing
  1219. Aat
  1220. Aat Bioquest
  1221. Abcam
  1222. Abi
  1223. Abm
  1224. Abnova
  1225. Abr
  1226. Abt
  1227. Abt Beads Technologies
  1228. Abx
  1229. Accu-Chek
  1230. Accurate Wirecraft Company
  1231. Accustandard
  1232. Ace Hose And Rubber Co.
  1233. Acl Incorporated
  1234. Acros
  1235. Act Test Panels Llc.
  1236. Actc
  1237. Adam Equipment, Inc.
  1238. Ademtech
  1239. Adg
  1240. Adi
  1241. Advanced Ceramics Manufacturing
  1242. Advanced Environmental Solutions Inc.
  1243. Advantech
  1244. Advent Electric Inc.
  1245. Affinity
  1246. Affymetrix
  1247. Agilent
  1248. Agilent Technologies
  1249. Ahlstrom Filtration Inc.
  1250. Air Technology Solutions
  1251. Airgas Safety
  1252. Air-Tite
  1253. Ak Limited
  1254. Akro-Mils
  1255. Alamarblue
  1256. Alconox Inc.
  1257. Alere
  1258. Alfa
  1259. All Foils Incorporated
  1260. Allen-Bradley
  1261. Allied K&R Broom & Bristle
  1262. Alnylam Pharmaceuticals
  1263. Alpha Innotech
  1264. Alpha Pro Tech, Ltd.
  1265. Alzet
  1266. Amaxa
  1267. Ambio
  1268. American Bantex Corp.
  1269. American Public Health
  1270. Amersham
  1271. Amgen
  1272. Ammex
  1273. Amnis
  1274. Ampac Flexibles
  1275. Anachemia Sciences
  1276. Andrews Glass Co.
  1277. Andwin Scientific Ind.
  1278. Ansell Healthcare
  1279. Antibodies
  1280. Apiezon Products
  1281. Apogee Designs Ltd.
  1282. Applied Biosystems
  1283. Applied Separations
  1284. Argos Technologies
  1285. Arrow Eng Company Inc.
  1286. Artron
  1287. Assaypro
  1288. Astral Diagnostics Inc.
  1289. Atago
  1290. Atago U.S.A. Inc.
  1291. Atra
  1292. Avanti
  1293. Avanti Polar
  1294. Avanti Polar Lipids
  1295. Avantor J.T.Baker
  1296. Avantor Macron
  1297. Avidity
  1298. Avitag Technology
  1299. Axis-Shield
  1300. Bacharach Inc
  1301. Bachem
  1302. Bangs
  1303. Bangslab
  1304. Barnant Company
  1305. Barnstead International
  1306. Bausch & Lomb
  1307. Bbi
  1308. Bbi Solutions
  1309. Bbl
  1310. Bd Bdis
  1311. Bd Biocoat
  1312. Bd Diagnostic
  1313. Bd Difco
  1314. Bd Falcon
  1315. Bd Labware
  1316. Bd Matrigel
  1317. Bd Pharmingen
  1318. Bd Pmg
  1319. Beckman Coulter
  1320. Becton Dickinson
  1321. Bel-Art Products
  1322. Belimed
  1323. Benchmark Scientific
  1324. Bender
  1325. Bennett Wood Spec, Inc.
  1326. Berkshire Corporation
  1327. Berthold
  1328. Bertin Pharma
  1329. Best Glove Inc.
  1330. Bethyl
  1331. Bevco Precision Manu. Co. Inc.
  1332. Biacore
  1333. Bico Incorporated
  1334. Binder
  1335. Binder Inc.
  1336. Bio Plas Inc.
  1337. Biocarta
  1338. Biocatalysts
  1339. Biochrom Ltd.
  1340. Biocompare
  1341. Biocontrol
  1342. Biodot
  1343. Biofire
  1344. Biohit
  1345. Bioiga
  1346. Bioind
  1347. Biomat
  1348. Biomatrica
  1349. Biomedia
  1350. Biomedica
  1351. Biomedical Polymers, Inc.
  1352. Biomedicals
  1353. Biomerieux
  1354. Biomiga
  1355. Bionexus Inc.
  1356. Bioporto
  1357. Bioprocessing
  1358. Bio-Rad
  1359. Bioscience Incorporated
  1360. Biosonda
  1361. Biosource
  1362. Biosynergy, Inc.
  1363. Biosystems
  1364. Biotech
  1365. Biotek
  1366. Bio-Tek
  1367. Biotek Instruments Inc.
  1368. Biotest
  1369. Biotools
  1370. Biovision
  1371. Biowest
  1372. Bioworld
  1373. Bio-X
  1374. Biozyme
  1375. Blacks Machine Co
  1376. Blazer Products
  1377. Boekel Industries Inc.
  1378. Boise Office Solutions
  1379. Boscom Incorporated
  1380. Boston Biochem
  1381. Bovogen
  1382. Brady
  1383. Brand
  1384. Brandtech Scientific Inc.
  1385. Branson Ultrasonics Corp.
  1386. Braun Brush Company
  1387. Brookfield Eng. Lab Inc.
  1388. Brush Tech
  1389. Brushes Corp.
  1390. Bti
  1391. Buchi Corporation
  1392. Bulbtronics
  1393. Burrell Corporation
  1394. Byk Gardner Usa
  1395. C & G Containers, Inc.
  1396. Cadence Science
  1397. Cambridge Diagnostic Product
  1398. Cambridge Environmental Prod
  1399. Cambridge Isotope Laboratories
  1400. Cannon Instrument Co.
  1401. Cannon Instruments Co.
  1402. Capitol Vial
  1403. Capp
  1404. Capricorn
  1405. Cardinal Health
  1406. Cargille R P Lab Inc.
  1407. Carltex Inc.
  1408. Carver Incorporated
  1409. Celex
  1410. Cell Point Scientific
  1411. Cell Signaling
  1412. Cell Systems
  1413. Cellgenix
  1414. Cellresearch
  1415. Celltreat Scientific Products
  1416. Celsis
  1417. Cerilliant
  1418. Chase Instruments
  1419. Chemetrics Inc.
  1420. Chemokine
  1421. Chemservice
  1422. Chromatography Res. Supplies
  1423. Chromogenix
  1424. Chrono-Log
  1425. Cil
  1426. Cleaver
  1427. Clodronate
  1428. Colder Products Company
  1429. Comfort Safety Products
  1430. Compass Inst. & Optical Co.
  1431. Conda
  1432. Continental Refrigerator
  1433. Cooper-Atkins Corporation
  1434. Coors Ceramicon Design Ltd.
  1435. Cordenpharma
  1436. Covance
  1437. Covaris
  1438. Cramer Inc.
  1439. Crosstex International
  1440. Crp
  1441. Csc Scientific Co. Inc.
  1442. Cst
  1443. Ctl
  1444. Current Technologies
  1445. Cusabio
  1446. Cybio
  1447. Cyclex
  1448. Davis Instruments
  1449. Decon
  1450. Decon Labs Inc.
  1451. Defelsko Corporation
  1452. Dharmacon
  1453. Dhigroup
  1454. Dickson Company
  1455. Digivac Company
  1456. Diversified Biotech
  1457. Dolan-Jenner
  1458. Dr.Ehrenstorfer
  1459. Dragonlab, Llc
  1460. Drg
  1461. Drummond Scientific Company
  1462. Dshb
  1463. Dupont
  1464. Dupont Personal Protection
  1465. Durable Corporation
  1466. Durable Safety Products
  1467. Durham Manufacturing Co.
  1468. Dynal
  1469. Dynalon Corporation
  1470. Eagle Mfg. Company
  1471. Eagle Thermoplastics Inc.
  1472. Eastcoast
  1473. Eastwood Manufacturing Co.
  1474. Eberbach Corporation
  1475. Echelon
  1476. Edvotek
  1477. Edwards
  1478. Elastin
  1479. Electron Microscopy Sciences
  1480. Eli Lilly
  1481. Ellsworth Adhesive Systems
  1482. Emerald
  1483. Endecotts
  1484. Endogen
  1485. Endozyme
  1486. Envirologix
  1487. Environmental Express
  1488. Enzo
  1489. Enzo Life Science
  1490. Ep Scientific Products
  1491. Eppendorf North America
  1492. Erdco Engineering Corp
  1493. Erie Scientific Co.
  1494. Esco
  1495. Esri
  1496. Euroscience
  1497. Evident
  1498. Excel Scientific
  1499. Exeter Analytical Inc.
  1500. Extech Instruments
  1501. Falcon Safety
  1502. Finescale Company
  1503. Finnzymes
  1504. Fischer Technical Company
  1505. Fitzgerald Industries International
  1506. Fluoromount-G
  1507. Fortebio
  1508. Frontier Scientific
  1509. G C Fuller
  1510. Gast Manufacturing, Inc.
  1511. Gbi
  1512. Ge Healthcare
  1513. Ge Osmonics
  1514. Gene
  1515. Gene Tools
  1516. Genesis
  1517. Gentex
  1518. Gentra
  1519. Genview
  1520. Gfschemicals
  1521. Glas Col Apparatus Company
  1522. Globe Scientific Inc.
  1523. Globozymes
  1524. Glycotech
  1525. Glycotope
  1526. Gosselin
  1527. Grant Instruments
  1528. Graphic Controls
  1529. Greiner
  1530. Hach
  1531. Hach Company
  1532. Hamilton Company
  1533. Hampton
  1534. Hanna
  1535. Hanna Instruments
  1536. Harlan
  1537. Harvard Apparatus Inc.
  1538. Hausser Scientific
  1539. Heathrow Scientific
  1540. Heidolph – Brinkmann
  1541. Helica
  1542. Hellma
  1543. Hemco Corporation
  1544. Hettich
  1545. Hf Scientific
  1546. Hhc
  1547. High Five Products
  1548. Honeywell Burdick & Jackson
  1549. Honeywell Safety Products
  1550. Htl
  1551. Humboldt Mfg. Co.
  1552. Hypermol
  1553. I .W. Tremont Co., Inc.
  1554. Iba
  1555. Ibex
  1556. Ibidi
  1557. Ibl
  1558. I-Chem
  1559. Ict
  1560. Idexx
  1561. Idexx Distribution, Inc.
  1562. Ids
  1563. Idt
  1564. Iec, Heraeus
  1565. Iic
  1566. Ika
  1567. Ika Works Inc.
  1568. Illumina
  1569. Ilshin-America
  1570. Immunogen
  1571. Immunoreagents
  1572. Imtec
  1573. Inalco
  1574. Inbio
  1575. Incell
  1576. Indigo Biosciences, Inc.
  1577. Inficon
  1578. Inorganic Ventures
  1579. Insight
  1580. Integra York Pa, Inc.
  1581. Integrated
  1582. Intergen
  1583. Interlab Supply
  1584. Intermetro Industries Corp.
  1585. International Cryogenics, Inc.
  1586. Interscience
  1587. Irvine
  1588. Irvine Scientific
  1589. Isis Pharmaceuticals
  1590. Isotope
  1591. Itw Dymon
  1592. Ivgn
  1593. Iwaki
  1594. J.G. Finneran Assoc. Inc.
  1595. Jackson
  1596. Jackson Immunoresearch
  1597. Jaece Industries Inc.
  1598. Jenco International
  1599. Jencons Scientific Ltd.
  1600. Jenway
  1601. Jo-1 Antigen
  1602. Johnson Nuclear
  1603. Jtbaker
  1604. Justman Brush Co.
  1605. Justrite Manufacturing Co.
  1606. Kd Scientific
  1607. Keller
  1608. Kent Elastomer Products Inc.
  1609. Kerry
  1610. Keur Industries Inc.
  1611. Kimberly Clark Industrial
  1612. Kimberly Clark Safety Div.
  1613. Kimble Chase/Kontes
  1614. Kinematica
  1615. Kitco Inc.
  1616. Knf Neuberger
  1617. Koehler Inst Co. Inc.
  1618. Koken
  1619. Konstance Pneumatics
  1620. Lab Armor, Llc.
  1621. Lab Glass
  1622. Lab Safety Supply
  1623. Lab Synergy
  1624. Labchem, Inc.
  1625. Labcon Incorporated
  1626. Labconco
  1627. Labcor Products
  1628. Labomed Inc.
  1629. Labplas Inc.
  1630. Labstrong Corporation
  1631. Lagasse Inc.
  1632. Lakeside Manufacturing Inc
  1633. Lamotte Company
  1634. Lancaster
  1635. Lauda-Brinkmann, Inc
  1636. Lawler Manufacturing Company
  1637. Lbm Lindberg Blue
  1638. Leica Biosystems Richmond, Inc.
  1639. Leneta Company
  1640. Lgcstandards
  1641. Life Span
  1642. Life Technologies
  1643. Lifespan
  1644. Linco
  1645. List Biological Laboratories
  1646. Little Giant Pump Company
  1647. Lkt Laboratories
  1648. Lsbio
  1649. Lucigen
  1650. Ludger
  1651. Luminex
  1652. Lumi-Phos
  1653. Lux Products Corp.
  1654. Macs
  1655. Magen
  1656. Marker Gene
  1657. Market Forge Company
  1658. Marvel/Div. Northland
  1659. Maryland Plastics Inc.
  1660. Master Appliance Corp
  1661. Matheson Instrument
  1662. Mattek
  1663. Max Professional
  1664. Maybridge
  1665. Mays Chemical Company
  1666. Mbi(Fermentas)
  1667. Mbl
  1668. Mediatech
  1669. Medicago
  1670. Medical Action Industries
  1671. Medisafe
  1672. Medline Industries
  1673. Medplus Services
  1674. Medsystems
  1675. Megazyme
  1676. Memmert
  1677. Merck
  1678. Mercodia
  1679. Metasystems
  1680. Metrohm Usa, Inc.
  1681. Mettler Toledo
  1682. Mettler-Toledo Inc.
  1683. Micro Essential Inc.
  1684. Microbix
  1685. Microflex
  1686. Micron Env. Industries
  1687. Microsource Discovery System
  1688. Miele
  1689. Millipore
  1690. Mirus
  1691. Mirusbio
  1692. Mitegen
  1693. Mo Bio Laboratories
  1694. Mobio
  1695. Molecular Bio-Products
  1696. Molecular Devices
  1697. Molecular Probes
  1698. Monarch Instruments
  1699. Motic Instruments Inc.
  1700. Mp Biomedicals
  1701. Mp Biomedicals Llc.
  1702. Mrc
  1703. Mti Corporation
  1704. Munktell
  1705. Munktell Inc.
  1706. Mynox
  1707. Nabertherm
  1708. Nalgene
  1709. Nasco
  1710. National Keystone Prod Inc.
  1711. National Marker Company
  1712. National Scientific
  1713. National Scientific Supply
  1714. N-Con System Company Inc.
  1715. Nds Technologies
  1716. Neogen
  1717. Neomarkers
  1718. Neta Scientific, Inc.
  1719. Newark Wire Cloth Co.
  1720. Newtex Industries Inc.
  1721. Next Advance, Inc
  1722. Neytech Div.
  1723. Nico Scientific Inc.
  1724. Nist
  1725. Norgen
  1726. Norgen Biotek
  1727. Nor-Lake Scientific
  1728. Novartis
  1729. Novatec
  1730. Novex
  1731. Nps Corp.
  1732. Nrd Incorporated
  1733. Nugen
  1734. Nunc
  1735. O’Berk Company
  1736. Oakton Instruments
  1737. Ohaus
  1738. Ohaus Scale Corporation
  1739. Omicron
  1740. Omicron Biochemicals
  1741. Omni International
  1742. Oncogen
  1743. One Lambda
  1744. Orbeco-Hellige Inc.
  1745. Oupont
  1746. Owl Separation Systems
  1747. Oxford
  1748. Oxis
  1749. P W Perkins
  1750. Pacific Transducer Corp
  1751. Pall
  1752. Palmero Health Care
  1753. Parafilm
  1754. Paris
  1755. Parker Hannifin
  1756. Peptides International
  1757. Perkinelmer
  1758. Pfizer
  1759. Pharmacia
  1760. Phipps & Bird
  1761. Phoenix
  1762. Phytotechnology Laboratories
  1763. Pierce
  1764. Pipette
  1765. Plas Labs
  1766. Plasticoid Company
  1767. Polarware Company
  1768. Polymeric Systems
  1769. Polypeptide
  1770. Polyplus
  1771. Polyplus Transfection
  1772. Pope Scientific Inc.
  1773. Precisa
  1774. Precision Gage & Tool
  1775. Precision Napco
  1776. Precision Systems Inc.
  1777. Profoldin
  1778. Promocell
  1779. Prospec
  1780. Protective Industrial Products
  1781. Pss
  1782. Puritan Medical Product Co.
  1783. Qcg System Llc
  1784. Qiagen
  1785. Qorpak
  1786. Qorpak, Div Of Berlin Packaging
  1787. Quality Environmental Containers
  1788. Quanta Biosciences
  1789. Quincy Lab Incorporated
  1790. Quincy Specialties Co.
  1791. R&D
  1792. Radnoti Glass Tech., Inc.
  1793. Rainin
  1794. Ramco
  1795. Rapidtest
  1796. Reci
  1797. Reichert Inc.
  1798. Research Diet
  1799. Research Diets
  1800. Resgen
  1801. Retsch
  1802. Revco
  1803. Ricca Chemicals
  1804. Richard Allan Scientific
  1805. Rl Instruments/Sentron Usa
  1806. Roberts Tool Company
  1807. Roche
  1808. Roche Applied Science
  1809. Romer
  1810. Rotronic Instrument Corp.
  1811. Rpi
  1812. Rti
  1813. S&S
  1814. Saint-Gobain
  1815. Saint-Gobain Ceramics
  1816. Saint-Gobain Performance Plastics
  1817. Salem Supply Company
  1818. Samco Scientific
  1819. Sample Ease
  1820. Santa Cruz
  1821. Sanyo
  1822. Sartorius
  1823. Sartorius Mechantronics
  1824. Sartorius Stedim
  1825. Sas Safety
  1826. Sba
  1827. Sceti
  1828. Schott
  1829. Schott Duran
  1830. Schuett
  1831. Sci Scientific
  1832. Scicominc
  1833. Scientific Industries
  1834. Scientific Instruments Inc.
  1835. Scientific Materials Co. Inc.
  1836. Scientific Specialties Inc.
  1837. Scientific Specialties Service, Inc.
  1838. Scipac
  1839. Scitech
  1840. Sdi
  1841. Seahorse
  1842. Seahorse Bioscience
  1843. Sekisui Diagnostics
  1844. Sensorex
  1845. Sera
  1846. Serana
  1847. Serva
  1848. Severn Trent Water Purif.
  1849. Seward Laboratory Systems, Inc.
  1850. Sge Incorporated
  1851. Shamrock Sci Spec Sys
  1852. Sheldon Manufacturing
  1853. Shimadzu Scientific Instruments, Inc.
  1854. Siemens Water Technology
  1855. Sigma-Aldrich
  1856. Signagen
  1857. Simport Scientific Inc.
  1858. Skc Incorporated
  1859. Smartpractice
  1860. Solar Light Company
  1861. So-Low Environmental
  1862. Sonics & Materials
  1863. Sorenson Bioscience
  1864. Specialized Products Co.
  1865. Spectrum Medical Industries Inc.
  1866. Sper Scientific
  1867. Spex Certiprep
  1868. Spex Sampleprep
  1869. Splash Shield Inc.
  1870. Srs Industries Inc.
  1871. Staco Incorporated
  1872. Stanford Research Systems
  1873. Starplex Scientific Corporation
  1874. Stemcell
  1875. Stoko Skincare
  1876. Sunshine Insdiv.
  1877. Sun-Sri
  1878. Supelco
  1879. Superior Manufacturing (Notrax)
  1880. Supermax Healthcare, Inc.
  1881. Surmodics
  1882. Synbiosis
  1883. Syngene
  1884. Takara
  1885. Taqman
  1886. Taylor Precision Product
  1887. Taylor-Wharton
  1888. Tbs
  1889. Techne
  1890. Techne Incorporated
  1891. Telstar
  1892. Tel-Tru Manufacturing Co.
  1893. Tempshield Incorporated
  1894. Testo Inc.
  1895. The Binding Site Group Ltd
  1896. Thermco Products, Inc
  1897. Thermo Fisher
  1898. Thermo Orion
  1899. Thermo Scientific
  1900. Thermo Uv-Vis
  1901. Tiangen
  1902. Tidi Products
  1903. Titan
  1904. Tlc
  1905. Toku-E
  1906. Tokyo Rikakikai, Co. Ltd.
  1907. Tomos
  1908. Toronto Research Chemicals
  1909. Torpac
  1910. Torrey Pines Scientific Inc.
  1911. Toyobo
  1912. Trc
  1913. Triangle Biomedical Science
  1914. Trippnt, Inc.
  1915. Tris
  1916. Troemner
  1917. Ttplabtech
  1918. Tufpak Inc.
  1919. Twd Tradewinds Inc.
  1920. U.S. Stoneware Corporation
  1921. Udy Corporation
  1922. Ultra Scientific
  1923. United Products & Inst.Inc.
  1924. United Scientific Supplies, Inc.
  1925. Uscnlife
  1926. Usp
  1927. Uvp
  1928. Uvp Llc.
  1929. Valutek
  1930. Van Note Enterprises Inc.
  1931. Varian
  1932. Vector
  1933. Vee Gee Scientific
  1934. Vistalab Technologies
  1935. Vitrolife
  1936. Vmd
  1937. Vysis
  1938. Wako
  1939. Waldmann Lighting
  1940. Waring Products Division
  1941. Warner
  1942. Water Saver Faucet Co.
  1943. Waters
  1944. Watson-Marlow Inc.
  1945. Wave
  1946. Wearwell
  1947. Welch Vacuum
  1948. Wesco Industrial Products
  1949. West Pharmaceutical Services
  1950. Westsystem
  1951. Whatman
  1952. Wheaton
  1953. Whip Mix Corporation
  1954. Wisconsin Aluminum Foundry
  1955. Wld-Tec
  1956. Worklon
  1957. Wtw
  1958. Wtw Nova Analytics
  1959. X-Rite
  1960. Yamato Scientific America
  1961. Zenoaq